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Given the apparent lack of exposure to xenobiotics known to precipitate methemoglobinemia, a working diagnosis of methemoglobinemia precipitated by emesis in the setting of possible heterozygous NADH methemoglobin reductase deficiency was made

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Other causes of microcytic anemia can include thalassemia, lead poisoning, and some types of anemia of chronic disease

Another approach to modulate NNMT involves bisubstrate inhibitors, which are designed to resemble both the substrate (NAM) and the cofactor (SAM)