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demonstrated that both basal and induced activity of transcription factor NF-E2-related factor 2 (Nrf2), a master regulator of antioxidant defense controlling a battery of antioxidant and detoxification genes, in maturing cortical neurons is extremely low due to epigenetic repression of the Nrf2 gene promoter 59

To date, isatuximab is the only clinically relevant anti-CD38 antibody shown to inhibit the catalytic activity of the enzyme (Table 2)

Really interesting findings and very aligned with what many of us are seeing

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