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The detrimental consequence of muscle transection outweighs crush injury, and after quadriceps muscle transection more VEGF and CD34 positive elements were present than after blunt trauma

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

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Among other things, he noted, this could help establish a recommended dose

Associated Press