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In vascular biology, the peptide seems to modulate nitric oxide synthesis, driving angiogenesis by upregulating eNOS and subsequent NO production

J Thorac Cardiovasc Surg 25(12):372-384, 2022

Many studies also rely on single or limited time-point sampling, pharmacological inhibition with pleiotropic effects, or global genetic models, all of which further constrain interpretation of temporal sequence and cell-specific causality

that is, cholesterol is converted to bile acids in the liver, 95% bile acids are absorbed by the distal ileum and returned to the liver, and 5% bile acids are excreted in the stool