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FeS@SRB-based PTT enhances anti-tumor immune responses Encouraged by the promising treatment efficiency of FeS@SRB-based therapy, we further examined the levels of tumor-associated immune cells and inflammatory factors after various treatments using an orthotopic 4T1 breast cancer-bearing mice model

Future directions First, define exposureresponse with quantitative pharmacokinetics and, where possible, receptor-occupancy or target-engagement biomarkers to guide dose selection across tissues

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To determine changes in mitochondria of LECs, HLEB3 cells and C57BL/6 J mice were pretreated with CeNPs, followed by UVB radiation (60 mJ/cm 2 for HLEB3 cells, 3.6 kJ/m 2 for mice), and corresponding samples were collected