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Although Tns4 is able to bind to the -subunit of integrins it lacks the actin-binding domain of the larger tensin isoforms (Lo and Lo, 2002

TGF-1 is one of the most abundant isoforms in the TGF- family, expressed by all renal resident and infiltrating inflammatory cells (164)

SLC7A11 and GPX4 form the main engine for GSH biosynthesis and utilization, and the SLC7A11/GSH/GPX4 axis is the major surveillance system for defense against ROS- dependent ferroptosis in cancer cells [31, 35, 64, 65]

However, the specific role of FR in oligodendrocyte differentiation and survival has not yet been directly confirmed and still needs experimental verification