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Structure assignment of the C-terminal loop was initially based on the best interpretable density region of the two complexes of the orthorhombic crystal forms

While the astrocyte-neuron lactate shuttle (ANLS) hypothesis (Pellerin and Magistretti, 1994), which emphasizes lactate transfer and its subsequent oxidative metabolism, has gained substantial experimental support, alternative viewpoints exist

This mechanism is of high relevance for the healing of poorly vascularized areas, such as myotendinous junctions, where limited blood flow often hampers the natural healing process

In some cases, it can be used as a cosmetic colorant as well (INCI name: CI 40800)

In research it has been studied for effects on skin remodeling, fibroblast activity, collagen and glycosaminoglycan synthesis, wound healing, and modulation of gene expression including studies showing changes in the expression of large numbers of genes in cultured cells