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The opposing effects of melatonin on tumor and normal cells may explain why its co-administration during radiotherapy can enhance radiosensitivity while also protecting normal cells from radiation-induced injury

We note that it will be important to examine if these observations are repeatable in vivo

10.1371/journal.pone.0185926 68 Narisawa-SaitoM.NawaH

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EGRIFTA WR TM should be discontinued if the patient has evidence of recurrent malignancy