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Recommendation 8: Primary and secondary treatment failure In patients with active axSpA and primary treatment failure with a first bDMARD (TNF inhibitor or IL-17 inhibitor), treatment with a bDMARD with a different mechanism of action (IL-17 inhibitor or TNF inhibitor, respectively) or a JAK inhibitor is strongly recommended

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whereas, in Minamata, Japan, there was direct industrial discharge of methylmercury

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[DOI] [PubMed] [Google Scholar] 15.Baranowski C., Martin H.G., Oyarzn D.A., Spinner A., Desai B., Petzold C.J., Nikolados E.M., Jaaks-Kraatz S., Scannell D., Sevey R., et al

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Huang L, Teng T, Bian B, Yao W, Yu X, Wang Z, et al

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Protective effects of N-acetylcysteine on a chemical-induced murine model of asthma

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