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Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia

(1) This is allowed by its structure as it is the shortest functional analog of endogenous GHRH with a C-terminal amidation that may help stabilize the molecule

Cancer history / active malignancy: compounds that promote angiogenesis and cell migration (BPC-157, TB-500) are generally treated as contraindicated where uncontrolled cell growth is a concern a standard caution across the recovery-peptide literature

Category 1 reclassification does not create an evidence base that didnt exist before