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One approach that has been reported consists of the use of pharmaceutical compounds with chaperone-like properties such as taurine-conjugated ursodeoxycholic acid derivative (TUDCA) and 4-phenylbutyric acid (PBA) that have the ability the improve the ER folding capacity ( Besides, pancreatic -cell ER stress is reported to be directly involved in the pathogeny of some forms of monogenic diabetes ( MODY-1 is caused by a point mutation of the hepatocyte nuclear factor 4 (HNF4) gene

Lund, A., Knop, F

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Its the rapidly swinging levels of both estrogen and progesterone that account for the vasomotor symptoms (hot flashes and night sweats) in perimenopausal and menopausal women 13