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None of these are available yet, but they represent where the field is heading over the next two to three years

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Using uniformly labeled glucose ([U- 13 C]glucose) increases the splitting of the resonance C4 of glutamate and glutamine due to J-coupling with position C5 (Henry et al., 13 C]lactate can be used as an alternative to [1,6- 13 C 2 ]glucose, but results in a reduced amount of labeling molecules because of a lower lactate entry into the brain as compared to [1,6- 13 C 2 ]glucose (Duarte et al., 13 C]acetate has the particularity of being metabolized almost exclusively in glia

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However, ultra-high-dose methylcobalamin therapy may improve the prognosis of patients with ALS, if administered early in the disease course, the researchers wrote