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Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in pediatric high grade glioma (pHGG)

54 In contrast, when animals were treated with tert-butylhydroperoxide to induce LPO-mediated liver injury, extensive LPOindicated by a 12- to 30-fold increase in these LPO parameterswas necessary to even cause moderate liver injury

By focusing on the AMPKPPAREZH2 axis, this review identifies potential molecular targets for improving fertility outcomes, while also underscoring how genomic and epigenomic insights are advancing reproductive biology and guiding novel therapeutic strategies

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