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Among the most promising non-incretin receptor targets are amylin (Amy) receptors (AMYRs), supported by data from phase I and phase II clinical trials showing efficacy of the long-acting amylin and calcitonin receptor agonist, cagrilinitide (Cagri), both as monotherapy 2,3 and in combination with the selective GLP-1R agonist, semaglutide 4,5

PubMed: (peer-reviewed) Hosokawa R, et al

Moreover, controlled release helped maintain an effective drug concentration for a longer period of time, which may reduce the need for frequent drug administration and improve patient compliance [53]

They can be synthesized and delivered as drugs

Higher doses do not always produce better results