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doi: 10.1038/nrm2330 51

These experimental results demonstrate that siRNA/Ap-CS formulation possesses the more desirable cellular permeability that is based on aptamer-mediated cancer cell-specific recognition and thus is able to execute the targeted siRNA delivery to tumor cells compared with the conventional nucleic acid-modified AuNPs similar to SNA 45,53,54,55

Route selection: IP or IM provides the best-characterised systemic PK

This biomarkerclinical discordance has also been observed in interventional supportive care trials, where biomarker modulation did not always predict clinical outcomes 32,33

Since prolonged exposure to CPAs can be toxic to cells, careful management of concentration and exposure time are critical