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showed that the injection of somatostatin-28 into the lateral brain ventricle blocked acute stressors-induced rise of ACTH and epinephrine plasma levels in rats (Brown et al., Brain corticotropin releasing factor signaling In 1950, Harris and colleagues reported that different stressors stimulate the release of adrenocorticotropic hormone (ACTH) via a yet unknown hypothalamic factor (de Groot and Harris, 1955)

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