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In mouse models of Alzheimer's disease, systemic administration of GHK-Cu for 12 weeks results in 30% improvement in cognitive function tests and 25% reduction in brain amyloid plaque burden compared to vehicle-treated controls

Both are GHRH analogs activating the same pituitary GHRHR, but with different pharmacokinetics

Mol Ther 19(10):17691779 Acknowledgements This research has been supported by Science and Engineering Research Board, India (EEQ/2020/000188)

When neuronal cells encounter extracellular stressors, unfolded proteins accumulate within the ER lumen, leading to ER stress

Moreover, risks of hematoma expansion, infection, and shivering-induced stress remain important safety concerns 73