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Researchers originally developed this compound as a modified fragment of human growth hormone (HGH) to target fat metabolism without causing many of the hormonal side effects associated with full growth hormone therapy

Methods 17 (3), 261272

Berberine activates AMPK through a different mechanism than MOTS-c (via inhibition of complex I in mitochondria), so concurrent use may create additive rather than synergistic AMPK activationhigher risk of hypoglycemia without proportional metabolic benefit

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