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From preclinical evidence to human studies: what makes a drug candidate ready for a First-in-Human trial

Trans-membrane tight junction proteins are linked to the actin-based cytoskeleton via zonula occludens-1, zonula occludens-2, zonula occludens-3, cingulin, acute lymphoblastic leukemia-1 fusion partner in chromosome 6, and 7H6 (also named barmotin), which may also play an essential role in modulating tight junction tightness [11]