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10.1016/j.bbamem.2011.04.002 77 MohandasN.AnX

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doi: 10.1016/j.cell.2014.12.019 105 SteynACrowtherNJNorrisSARabionetREstivillXRamsayM

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Thymoquinone activates the Nrf2/heme oxygenase-1 (HO-1) pathway, promotes Nrf2 nuclear translocation, upregulates antioxidant gene expression, and downregulates pro-inflammatory cytokines, such as interleukin-1 (IL-1), contributing to cellular protection

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A slightly oxidative environment also helps preserve sensitive norisoprenoids, such as -damascenone, although thiols may be diminished through oxidative degradation

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Investigation of eNOS Gene Polymorphism Exposes a Genetic Association between Endothelial Dysfunction and Osteoporosis in Postmenopausal Women. Menopause (New York, N.Y.) , vol

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