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To assess whether MitoQ treatment can similarly overcome the differentiation block observed with DPI (16), MNA IMR-5/75 cells were treated every two days with either 50 nM or 100 nM MitoQ and monitored by microscopy ( Figure 1G )

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When glycine binds to inhibitory glycine receptors (chloride-channel complexes), it causes an influx of chloride ions into neurons, hyperpolarizing the cell membrane and thereby reducing neuronal excitability