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In contrast, clinical metabolomic analyses of KD have reported increases in specific BCAAs, such as valine, and improvement of AD-related risk factors such as increased HDL-C and reduced BMI, suggesting that BCAA dynamics may differ depending on the disease stage and metabolic context [35]

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Inflammatory biomarkers of low back pain and disc degeneration: a review

In the centrilobular hepatocytes, there was substantial proliferation of rough endoplasmic reticulum, as shown by electron microscopy with slightly less than half of the periportal hepatocytes showing rough endoplasmic reticulum proliferation