glutathione and napqi Alcohol paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting Metabolic pathway for NAPQI formation

Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram Most people don't realise this Paracetamol breaks down into a toxic compound called NAPQI. Your liver neutralizes it using glutathione (your body's defense shield). But when you take it too often 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. Critical care toxicology for acetaminophen overdose Mitochondrial damage produced by Nacetylpbenzoquinone imine (NAPQI). Download Scientific Diagram

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