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The AD pathogenesis is typified by the development of Tau protein-containing neurofibrillary knots and senile plaques, which are composed of A polypeptides (Serrano-Pozo et al., 2011

[DOI] [PMC free article] [PubMed] [Google Scholar] (64).Tang X

TABLE 1 Clinical trials using GHRH

The organic combination of specific therapeutic nucleic acid molecules, targeted modifications, and functionalized delivery carriers may become vital to achieving personalized nucleic acid therapy and addressing unmet clinical needs

At day seven of culture, the cells had completely differentiated into bone marrowderived macrophages (BMDMs) and the macrophages obtained were counted (4x10 5 or 2x10 5 cells/well, in case of co-culture) and seeded in 24-well plates for the in vitro experiments