pentose phosphate pathway and glutathione Multiomics reveal the central role

However, hepatic SIRT6 overexpression in mice has been found to reverse ethanol-induced damage by enhancing transcriptional the induction of Mt1 and Mt2 genes and improving the hepatic defense system against alcohol toxicity [95]

30 DissanayakeIHZakVKaurKJayeKAyatiZChangDet al

Heffernan, M., Summers, R

Nutraceuticals in the management and prevention of Alzheimers disease

The decrease of GSH can be explained by an increase in its use by hepatic cells, and by a decrease in the synthesis of GSH or an increase in its degradation during oxidative stress [31], because it participates in the ROS detoxification reactions [32]