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We recognized some limitations of the current PFS ratesetting methodology but maintained that the approach was the most appropriate at the time

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For a long time, astrocytes were considered a rather homogeneous cell population across the entire brain

"Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide"

The practical protocol approach for most researchers starts at a lower dose, typically 2mg weekly, and escalates every three to four weeks based on tolerance