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Pharmaceutical wastewater treatment plants (PWWTPs) that receive effluents from bulk-drug manufacturing facilities constitute extreme selective environments in which antibiotic concentrations can reach the mg/L rangeorders of magnitude higher than in municipal or hospital wastewaters 14,47

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111 Furthermore, diabetes disrupts brain iron homeostasis, leading to neurotoxicity through inflammation, increased BBB permeability, altered iron ion redistribution, and impaired iron metabolism