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TrxR utilizes NADPH to reduce Trx, reducing target proteins through its conserved thiol groups, thereby maintaining cellular redox balance

Vitamin E can directly affect the production of inflammatory factors and the activation of inflammatory pathways through molecular mechanisms such as lipid metabolism and immune regulation.-tocopherol can reduce inflammation in the liver by inhibiting JNK/c-Jun, and inhibit JNK/CHOP apoptosis signal to reduce hepatocyte apoptosis, while down-regulating autophagy overactivation and HSCs activation, thereby reducing liver fibrosis (91)

Metaye T, Levillain P, Kraimps JL, Perdrisot R

Second: Try Construct Modifications If conditions can't rescue the cleavage, make a new construct