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Moreover, emerging evidence indicates that CNMs can be fermented by gut bacteria into bioactive metabolites like butyrate, which then modulate host physiology, such as intestinal stem cell differentiation highlighting not only toxicological but also transformative microbialhost interactions ( in vitro systems such as gut-on-chip platforms are increasingly integrated into tiered risk frameworks to enhance hazard identification without excessive animal use

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Yin L, Mano J, Tanaka K et al (2017) High level of reduced glutathione contributes to detoxification of lipid peroxide-derived reactive carbonyl species in transgenic Arabidopsis overexpressing glutathione reductase under aluminum stress

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