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Platinum-based drugs: past, present and future

Prostaglandin E2 (PGE2), the most important bioactive mediator secreted by neutrophils, accelerates blood flow and produces oedema and pain, and its synthesis is primarily related to AA, which is related to LDs (Kawahara et al., 2015)

The accumulation of lipid droplets, rich in polyunsaturated fatty acids (PUFAs), also creates vulnerability to ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation [18, 19]

These simulations reveal altered binding sites, structural changes, and disrupted interactions, shedding light on disease mechanisms

(PubMed) Czeizel AE, Dudas I, Vereczkey A, Banhidy F