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Efferocytosis via LRP1 (187) and SR-BI (185) also stimulates signaling pathways leading to pAkt production to promote phagocyte survival

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Biochemistry 5 AntonioniA.FantiniC.DimauroI.CaporossiD

Notably, several studies have shown that IIRI can be significantly mitigated by blocking ferroptosis with exogenous antioxidants such as resveratrol or by promoting GPX4 expression through the activation of transient receptor potential vanilloid 1 (TRPV1) in animal models [9, 10]

For cirrhosis (F4), it has an AUROC of 0.783, Sn 91.4%, specificity (Sp) 79.3%, PPV 93.3%, and a negative predictive value of 47.9%