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Description

A new derivate of DOX, 4-acetyl-2-nitro-benzenesulfonyl doxorubicin (ANS-DOX) was synthesized and shown to be converted into DOX by MGST1 and GSTA1-1, whereas no activity was observed for GSTP1-1 128

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These superoxide anions are highly reactive and require detoxification by mitochondrial SOD2, which converts them into hydrogen peroxide (35)

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