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In addition, crizotinib potently inhibited HGF-stimulated endothelial cell survival or invasion and serum-stimulated tubulogenesis in vitro, suggesting that this agent also exhibits antiangiogenic properties [71, 72]

It also has anti-inflammatory effects, decreasing the pro-inflammatory cytokines TNF-, IL-6, MCP-1 and IL-1 in serum and liver, and inhibiting the TLR4/NFkB pathway