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Neuropathic pain worsens cognitive and mood functions and quality of life and is treated with antiepileptic and/or antidepressant drugs targeting the abnormal somatosensory nervous systems (Nicholson and Verma, 2004

There are several processes that contribute to mitochondrial quality control, including UPR mt , mitophagy, mitochondrial membrane dynamics, and mitochondrial biogenesis 13,89

Polysaccharides are also known to exert neuroprotective effects on mitochondria by reducing the ratio of Bax/Bcl-2, caspase-3 (Yu et al., 2017), P-AKT, and phosphoric acid

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Additionally, circadian disruption is associated with metabolic abnormalities that may drive the co-occurrence of diabetic nephropathy and DR