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These oxygen free radicals lead to lipid, protein, and DNA damage inside cells, which leads to structural and functional abnormalities in periodontal tissues and escalates disease progression

Kao C-T, Lin C-T, Chou C-L, Lin C-C

The value of GSH as an immunopharmacologic agent is that it can finetune immune response in a disease-dependent and redox state-dependent manner which differs from typical broad-effect immunosuppressive treatments (Figure 3)

Combined with localized hydrogel delivery and the absence of observable systemic toxicity in vivo, these findings suggest that the administered dose falls within a tolerable safety range

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