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Modern pharmacological studies have reported that tetramethylpyrazine (TMP), an active metabolite in Ligusticum chuanxiong , possesses various physiological functions, including antioxidant capabilities, anti-inflammatory actions, anti-apoptotic characteristics, the ability to regulate autophagy, vasodilatory functions, modulation of angiogenesis, inhibition of mitochondrial damage, safeguarding of endothelial cells, and mitigation of vascular smooth muscle cell proliferation and migration, and also offers neuroprotective benefits ( in vivo experiments using a mouse model of focal ischemic stroke (IS), TMP upregulates the expression of monocyte chemoattractant protein-induced protein one to inhibit neuroinflammatory responses, while protecting the integrity of the BBB ( Ligusticum chuanxiong

A week later, he had recurrence of symptoms with redness of the left eye followed by irritation, pain, photophobia, and blurry vision

MDF = 0.44) and progression to LRE (HR = 1.82 [1.1-3.0])

The key molecules in signaling pathways associated with glycolysis (e.g., PDK4), OXPHOS (e.g., IDH1 and KG), glutaminolysis (e.g., glutaminase), PPP (e.g., G6PD and NADPH), and P53 pathway are critically involved in regulating ferroptosis in ovarian cancer [12]

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