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Affected dogs may present with weakness, ataxia, disorientation, behavioural changes, collapse or seizures

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HM30-tesirine treatment of NSCLC tumour-bearing mice 3 10 6 H460 cancer cells in 100 L PBS or 5 10 6 H1299 cancer cells in 50 L PBS, 50 L Matrigel (Corning) were injected subcutaneously into female Balb/C nu/nu mice aged 69 weeks (Charles River Laboratories)

Simvastatin combined with resistance training improves outcomes in patients with chronic heart failure by modulating mitochondrial membrane potential and the Janus Kinase/Signal transducer and activator of Transcription 3 signaling pathways

Methotrexate exacerbates NAFLD by inhibiting antioxidant activity, boosting lipid buildup, and generating mitochondrial dysfunction, which leads to increased hepatocyte apoptosis and inflammation