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Similarly, in AML, An optimized genome-wide CRISPR screen revealed 492 AML-specific essential genes, including both known and novel therapeutic targets

The single dose, short (1 h) observation period, and lack of placebo arm are limitations in this proof-of-concept study and provide direction for follow-up studies

13 Moreover, AARS2 is capable of directly catalyzing L-lactate for ATP-dependent lactylation

Omega-3 fatty acids influence the arachidonic acid cascade by inhibiting the formation of final metabolites such as prostaglandins, thromboxanes, and leukotrienes