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With in-depth research, various hypotheses about the pathogenesis of depression have been supported, and people have begun to recognize that depression is the result of the combined effects of multiple factors, including the neuroendocrine, immune system, and gut microbiota

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Plasma Hcy was assayed by an enzymatic method measuring S-adenosylmethionine catalyzed by homocysteine-S-methyltransferase

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[] Both mechanisms ultimately lead to the formation of mitophagosomes and lysosomal degradation