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Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways

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For instance, in a study where a chimeric AARS mutant was developed by combining the tRNA binding domain of PylRS with the catalytic domain of Ec HisRS, researchers utilized a chimeric tRNA based on tRNA Pyl (Figure 9) This chimeric tRNA, featuring only a partial replacement of the acceptor stem with Ec tRNA His , facilitated recognition and UAA charging by the chimeric AARS

Additionally, the lack of stomach acid increases the amount of bacteria that use B12, making less of the vitamin available for the body to use

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