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Perioli L, Ambrogi V, Giovagnoli S, Ricci M, Blasi P, Rossi C

The nanoparticles improved MMP, reflected by an aggregate/monomer fluorescence ratio of 6.3 0.2 versus 3.7 0.2 in untreated, 1-methyl-4-phenylpyridinium (MPP+)-damaged cells (MPP is a neurotoxic compound causing mitochondrial dysfunction and neuronal cell death)

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Both genetic alterations and posttranslational mechanisms have been examined, and recently a key role for cytoskeleton proteins-mediated regulation has emerged, as discussed below