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Previous studies established that CAT inhibits ferroptosis by activating transient receptor potential vanilloid type 1 (TRPV1), thereby upregulating GPX4 expression and ameliorating intestinal ischemiareperfusion injury as well as organoid hypoxia-reoxygenation injury (Deng et al., 2021)

10.1038/mp.2011.165 9

Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis

Research has shown that individuals with depression, particularly those experiencing recurrent episodes, exhibit significantly elevated levels of 8-OHdG compared to normal levels (Omari Shekaftik and Nasirzadeh, 2021