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Autophagy and tumorigenesis

Downstream to RAS, the RAS-MEK-ERK and phosphatidylinositol-3 kinase (PI3K)-AKT/PKB pathways (see Chap

This step is the primary rate-limiting bottleneck of fatty acid oxidation

Over 200 nucleotides long, these transcripts fold into intricate structures that interact with proteins, RNA, or DNA to affect cellular signaling pathways and gene expression [375, 376]

After incubation, the treated cells were lysed with 0.1 M phosphate buffer pH 7.4 containing protease inhibitor cocktails (Merck, USA), followed sonication technique on ice for 1 min using ultrasonic homogenizer sonicator (CPX600, Ultrasonic Processor, Cole-Parmer, USA)