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Copper deficiency primarily leads to myocardial hypertrophy, remodeling, and alterations in systolic and diastolic function

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Wang T, Kuo C, Jan K, Huang H

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Further studies found that AUF1 interacts with the coding sequence and 3-untranslated region (UTR) of Nrf2 to stabilise the gene, whereas AUF1 binding to the 3-UTR of activating transcription factor 3 ( ATF3 ) promotes degradation of the gene, producing an anti-ferroptosis effect and ameliorating ALI [68]