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13 Cyanosis is not specific for methemoglobinemia

This makes sense when you understand the mechanism: oxidative stress damages the cells in your pancreas that produce insulin, and it interferes with insulin signaling at the cellular level

[DOI] [PubMed] [Google Scholar] 244.Olson N

Additionally, our in vivo experiments confirmed low levels of GSH in skeletal muscle of aged mice with a concomitant accumulation of carbonylated/nitrosylated proteins, as an index of oxidative/nitrosative stress, and an increased level of muscular atrophy markers and of pro-inflammatory cytokines