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Acknowledgments The authors would like to express their sincere appreciation to Clive Chen Clinic, Taichung, Taiwan, and the Department of Neurosurgery, Yuan Rung Hospital, for their valuable support and assistance in the completion of this study

Introduction Parkinsons disease (PD) is the second most common neurodegenerative disease worldwide with 6.1 million patients globally in 2016 (Postuma et al., 2015)