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Glycogenolysis: PLP is required for the breakdown of glycogen, the storage form of glucose in the liver and muscle tissue

John's Wort (50 and 100 mg/kg) treatment significantly caused anti-anxiety-like behavior (shortened time latency to enter in mirror chamber, increased average time spent per entry in mirror chamber) and improved locomotor activity (increased ambulatory movements) as compared to control (restraint stress) animals

Several lines of evidence support the involvement of oxidative stress in fibrotic lung disease 8,9

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In the external validation, the EACH score demonstrated superior predictive performance with an AUC of 0.784 (95% CI 0.694-0.871) compared with a traditional score(AUC = 0.528, 95% CI 0.457-0.619) and another ML-based scoring generator (AUC = 0.784, 95% CI 0.694-0.871)