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Labeling of cultured neurons with Nb/Ab by spontaneous endocytosis Labeling of neurons was performed as described before 63 although with the following modifications

Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival

This can result in deeper and more restful sleep, ultimately improving the individuals quality of life (30)

Crooks, G

These regions were chosen because of their putative role in the neural mechanisms of ME/CFS and long COVID, in particular with regard to the integration of information from various levels [33, 34], with pgACC key for emotional regulation and autonomic integration, and dACC - for cognition [35, 36]