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Newborns and infants up to the age of 6 months of age can develop hemorrhagic bleeding as a result of a Vitamin K deficiency (Vitamin K Deficiency Bleeding)

Int J Pharm Pharm Sci 3 Singh M, Chitranshi N, Singh AP et al (2012) An overview on fast disintegrating sublingual tablets

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For example, consider switching to a VKA when a CYP3A4 or Pgp inhibitor leads to a doubling of the exposure (AUC) of a DOAC, or when an inducer leads to a reduction of at least 20% in its AUC (Steffel et al., 2021