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Through metabolomic analysis of T2DM and DKD patients, they found that N-acetylaspartate, L-valine, betaine, isoleucine, asparagine, and L-methionine were significantly elevated in DKD patients, with high levels of L-leucine and isoleucine significantly associated with rapid estimated glomerular filtration rate (eGFR) decline

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In contrast, GGCT knockdown led to a significant increase in the extracellular acidification rate (ECAR) (Fig